Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study
Giovanni Adami1, Giovanni Arioli2, Gerolamo Bianchi3, Maria Luisa Brandi4, Carla Caffarelli5, Luisella Cianferotti4, Davide Gatti1, Giuseppe Girasole3, Stefano Gonnelli5, Monica Manfredini2, Maurizio Muratore6, Eugenio Quarta6, Laura Quarta6
Published: Bone. 2020 May;134:115297
The identification of patients at risk for fragility fractures who may benefit from osteoporosis treatments is a challenge to clinicians. With this prospective observational study, the authors investigated the effectiveness of the T-score values provided by Radiofrequency Echographic Multi-Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures, comparing the performance of REMS with the Dual-energy X-ray Absorptiometry (DXA) one in a 5-years follow-up.
The studied population were over 1500 women from 30 to 90 years old who underwent REMS and DXA scans at femoral and vertebral sites. Among the findings of this study, a high agreement between REMS- and DXA-measured bone mineral density (BMD) values was observed. As concerning fragility fractures, a relationship between lower T-score values and higher fracture rate was observed, as expected.
Considering the reference T-score threshold value of −2.5 to distinguish between osteoporotic and non-osteoporotic patients, REMS showed higher sensitivity than DXA at the vertebral site in the identification of incident fragility fracture (65.1% versus 57.7%, respectively), whereas the performance were comparable between techniques for the femoral site. REMS T-score resulted an effective predictor of the occurrence of incident fragility fractures, representing a valuable approach to enhance osteoporosis diagnosis in clinical routine.
1 Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy
2 Department of Neurosciences and Rehabilitation, “Carlo Poma” Hospital, ASST-Mantova, Mantova, Italy
3 SC Rheumatology, ASL 3 Genovese, Genoa, Italy
4 Department of Experimental and Clinical Biomedical Sciences, University of Florence, Metabolic Bone Diseases Unit, University Hospital of Florence, Florence, Italy
5 Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy
6 O.U. of Rheumatology, “Galateo” Hospital, San Cesario di Lecce ASL-LE, Lecce, Italy
REMS for the diagnosis of osteoporosis in a European multicenter clinical context Bernard Cortet, Elaine Dennison, Adolfo Diez-Perez, Médéa Loquet, Maurizio Muratore, Xavier Nogués, Diana Ovejero Crespo, Eugenio Quarta, Maria Luisa Brandi Department of Rheumatology...
The scientific study winner of the ISCD Abstract Award 2020 "Use of REMS technology in patients with spine artifacts.: A new diagnostic opportunity" M.D. Tomai Pitinca, C. Caffarelli, S. Gonnelli Department of Medicine, Surgery and Neuroscience, University of Siena,...
First assessment of maternal status during pregnancy by means of REMS (Radiofrequency Echographic Multi-Spectrometry) technology V.A. Degennaro1, G. Cagninelli1, F.A.Lombardi2, P. Pisani2, F. Conversano2, S. Casciaro2, S. Fieni1, T. Frusca1, T. Ghi1 1Department of...