REMS for the diagnosis of osteoporosis in a European multicenter clinical context

Bernard Cortet, Elaine Dennison, Adolfo Diez-Perez, Médéa Loquet, Maurizio Muratore, Xavier Nogués, Diana Ovejero Crespo, Eugenio Quarta, Maria Luisa Brandi

Department of Rheumatology and EA 4490, University Hospital of Lille, Lille, France

MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK

Muscoloskeletal Research Group, IMIM (Hospital del Mar Medical Research Institute), Centro de Investigaciòn Biomédica en Red en Fragilidad Y Envejecimiento Saludable (CIBERFES), ISCIII, Barcelona, Catalonia, Spain

Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium

Vito Fazzi Hospital, Lecce, Italy

FirmoLab Fondazione F.I.R.M.O.

Department of Biological, Experimental and Clinical Sciences, University of Florence, Florence, Italy

Published on: Bone Journal


This work shows the results of an international multicenter clinical study carried out by some of the most important European clinical centres for the diagnosis and management of osteoporosis. More than 4000 women, with age between 30 and 90 years, have been enrolled for the study and all of them underwent REMS and DXA scan on both the axial sites, femoral neck and lumbar spine. The analysis of the collected data confirms the higher sensitivity and specificity of REMS technology compared to DXA in discriminating between osteoporotic and non-osteoporotic patients; as well as the high diagnostic concordance between the two densitometry methods, being higher than 90% for both the axial sites. Moreover, this study shows the excellent performance of REMS T-Score, compared to DXA T-score, in identifying those patients suffering from previous fractures


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