Radiofrequency Echographic Multi Spectrometry (REMS) technology and DXA for BMD assessment in kidney transplant recipients

Fassio 1, S. Andreola2, D. Gatti1, M. Gatti1, G. Gambaro2, M. Rossini 1, P. Pisani 3, F. A. Lombardi 3, G. Adami1

1 Rheumatology Unit, University of Verona, Verona, Italy

2 Nephrology Unit, University of Verona, Verona, Italy

3 Institute of Clinical Physiology, National Research Council, Lecce, Italy

The clinical management of bone diseases in kidney transplant patients (KTR) is complex due to both, the frequent persistence of Chronic Renal Disease (CKD) and the physiological aging process, leading to a continuous need for regular bone health status monitoring. In this study, REMS has shown to possess good reliability in the assessment of bone mineral density for osteoporosis diagnosis in a female KTR cohort, in comparison with the gold standard DXA. Spinal investigation with REMS revealed a significantly lower bone mass than the DXA measurement. As a consequence, REMS seems to be more sensitive than DXA in the detection of early bone impairment and improves the classification of KTR patients characterized by a reduced bone mass. These findings suggest that REMS may be a robust diagnostic tool for monitoring bone changes in the overall CKD population.

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